Cardiac Magnetic Resonance for Early Detection of Radiation Therapy-Induced Cardiotoxicity in a Small Animal Model.

ABSTRACT:

Background

Over half of all cancer patients receive radiation therapy (RT). However, radiation exposure to the heart can cause cardiotoxicity. Nevertheless, there is a paucity of data on RT-induced cardiac damage, with limited understanding of safe regional RT doses, early detection, prevention and management. A common initial feature of cardiotoxicity is asymptomatic dysfunction, which if left untreated may progress to heart failure. The current paradigm for cardiotoxicity detection and management relies primarily upon assessment of ejection fraction (EF). However, cardiac injury can occur without a clear change in EF.

Objectives

To identify magnetic resonance imaging (MRI) markers of early RT-induced cardiac dysfunction.

Methods

We investigated the effect of RT on g

SUBMITTER: Ibrahim EH 

PROVIDER: S-EPMC8078846 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature