Classification of electrophysiological and morphological neuron types in the mouse visual cortex.

ABSTRACT: Understanding the diversity of cell types in the brain has been an enduring challenge and requires detailed characterization of individual neurons in multiple dimensions. To systematically profile morpho-electric properties of mammalian neurons, we established a single-cell characterization pipeline using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions. We built a publicly accessible online database, the Allen Cell Types Database, to display these datasets. Intrinsic physiological properties were measured from 1,938 neurons from the adult laboratory mouse visual cortex, morphological properties were measured from 461 reconstructed neurons, and 452 neurons had both measurements available. Quantitative features were used to classify neurons int

SUBMITTER: Gouwens NW 

PROVIDER: S-EPMC8078853 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature