In Vitro Biosensing of β-Amyloid Peptide Aggregation Dynamics using a Biological Nanopore.

ABSTRACT: Alzheimer's disease and other neurodegenerative disorders are becoming more prevalent as advances in technology and medicine increase living standards and life expectancy. Alzheimer's disease is thought to initiate development early in the patient's life and progresses continuously into old age. This process is characterized molecularly by the amyloid hypothesis, which asserts that self-aggregating amyloid peptides are core to the pathophysiology in Alzheimer's progression. Precise quantification of amyloid peptides in human bodily fluid samples (i.e. cerebrospinal fluid, blood) may inform diagnosis and prognosis, and has been studied using established biosensing technologies like liquid chromatography, mass spectrometry, and immunoassays. However, existing methods are challenged to

SUBMITTER: Lenhart B 

PROVIDER: S-EPMC8078859 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature