Deregulation of imprinted genes expression and epigenetic regulators in placental tissue from intrauterine growth restriction.

ABSTRACT:

Purpose

Intrauterine growth restriction (IUGR) is a fetal growth complication that can be caused by ineffective nutrient transfer from the mother to the fetus via the placenta. Abnormal placental development and function have been correlated with abnormal expression of imprinted genes, which are regulated by epigenetic modifications at imprinting control regions (ICRs). In this study, we analyzed the expression of imprinted genes known to be involved in fetal growth and epigenetic regulators involved in DNA methylation, as well as DNA methylation at the KvDMR1 imprinting control region and global levels of DNA hydroxymethylation, in IUGR cases.

Methods

Expression levels of imprinted genes and epigenetic regulators were analyzed in term placental samples from 21 IUGR cases an

SUBMITTER: Canicais C 

PROVIDER: S-EPMC8079450 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature