The msaABCR Operon Regulates Persister Formation by Modulating Energy Metabolism in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is a major human pathogen that causes chronic, systemic infections, and the recalcitrance of these infections is mainly due to the presence of persister cells, which are a bacterial subpopulation that exhibits extreme, yet transient, antibiotic tolerance accompanied by a transient halt in growth. However, upon cessation of antibiotic treatment, a resumption in growth of persister cells causes recurrence of infections and treatment failure. Previously, we reported the involvement of msaABCR in several important staphylococcal phenotypes, including the formation of persister cells. Additionally, observations of the regulation of several metabolic genes by the msaABCR operon in transcriptomics and proteomics analyses have suggested its role in the me

SUBMITTER: Pandey S 

PROVIDER: S-EPMC8079656 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature