Stress enhances hippocampal neuronal synchrony and alters ripple-spike interaction.

ABSTRACT: Adverse effects of chronic stress include anxiety, depression, and memory deficits. Some of these stress-induced behavioural deficits are mediated by impaired hippocampal function. Much of our current understanding about how stress affects the hippocampus has been derived from post-mortem analyses of brain slices at fixed time points. Consequently, neural signatures of an ongoing stressful experiences in the intact brain of awake animals and their links to later hippocampal dysfunction remain poorly understood. Further, no information is available on the impact of stress on sharp-wave ripples (SPW-Rs), high frequency oscillation transients crucial for memory consolidation. Here, we used in vivo tetrode recordings to analyze the dynamic impact of 10 days of immobilization stress on n

SUBMITTER: Tomar A 

PROVIDER: S-EPMC8079661 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature