ATP2C2 Has Potential to Define Tumor Microenvironment in Breast Cancer.

ABSTRACT: Tumor microenvironment (TME) is vital for the occurrence and development of breast cancer (BRCA). However, it remains challenging to understand the dynamic modulation of the stromal and immune components comprehensively in TME. Herein, we used ESTIMATE and CIBERSORT algorithm to estimate the number of stromal and immune components and the abundance of tumor-infiltrating immune cells (TICs) in 582 BRCA cases from gene expression omnibus (GEO) database. We employed three regression models including univariable Cox proportion, LASSO regression model and multivariate Cox regression, and identified 7 immune-specific genes related to BRCA survival. Of 7 genes, ATPase Secretory Pathway Ca²⁺ Transporting 2 (ATP2C2) attracts our attention for significantly predicting prognosis of BRCA pa

SUBMITTER: Liu J 

PROVIDER: S-EPMC8079766 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature