The Redox-Active Tyrosine Is Essential for Proton Pumping in Cytochrome c Oxidase.

ABSTRACT: Cellular respiration involves electron transport via a number of enzyme complexes to the terminal Cytochrome c oxidase (CcO), in which molecular oxygen is reduced to water. The free energy released in the reduction process is used to establish a transmembrane electrochemical gradient, via two processes, both corresponding to charge transport across the membrane in which the enzymes are embedded. First, the reduction chemistry occurring in the active site of CcO is electrogenic, which means that the electrons and protons are delivered from opposite sides of the membrane. Second, the exergonic chemistry is coupled to translocation of protons across the entire membrane, referred to as proton pumping. In the largest subfamily of the CcO enzymes, the A-family, one pr

SUBMITTER: Blomberg MRA 

PROVIDER: S-EPMC8079940 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature