Transcriptome Signatures Predict Phenotypic Variations of <i>Candida auris</i>.

ABSTRACT: Health care facilities are facing serious threats by the recently emerging human fungal pathogen Candida auris owing to its pronounced antifungal multidrug resistance and poor diagnostic tools. Distinct C. auris clades evolved seemingly simultaneously at independent geographical locations and display both genetic and phenotypic diversity. Although comparative genomics and phenotypic profiling studies are increasing, we still lack mechanistic knowledge about the C. auris species diversification and clinical heterogeneity. Since gene expression variability impacts phenotypic plasticity, we aimed to characterize transcriptomic signatures of C. auris patient isolates with distinct antifungal susceptibility profiles in this study. First, we employed an antifungal sus

SUBMITTER: Jenull S 

PROVIDER: S-EPMC8079977 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature