Shared evolutionary footprints suggest mitochondrial oxidative damage underlies multiple complex I losses in fungi.

ABSTRACT: Oxidative phosphorylation is among the most conserved mitochondrial pathways. However, one of the cornerstones of this pathway, the multi-protein complex NADH : ubiquinone oxidoreductase (complex I) has been lost multiple independent times in diverse eukaryotic lineages. The causes and consequences of these convergent losses remain poorly understood. Here, we used a comparative genomics approach to reconstruct evolutionary paths leading to complex I loss and infer possible evolutionary scenarios. By mining available mitochondrial and nuclear genomes, we identified eight independent events of mitochondrial complex I loss across eukaryotes, of which six occurred in fungal lineages. We focused on three recent loss events that affect closely related fungal species, and inferred genomic changes

SUBMITTER: Schikora-Tamarit MA 

PROVIDER: S-EPMC8080010 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature