APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival.

ABSTRACT:

Background

Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays a critical role in DNA base excision repair (BER) pathway and has been reported to be overexpressed in multiple cancers. Previously, we have shown that histone chaperone FACT complex (Facilitates Chromatin Transcription, a heterodimer of SSRP1 and SPT16 proteins) facilitates the chromatin access and DNA repair function of APE1, and their expression levels are correlated with promoting drug resistance in cancer. FACT inhibitor has been introduced in phase I and II clinical trials for chemosensitization of advanced solid cancers. However, the expression profile and prognostic significance of APE1 and FACT complex in bladder cancer remains largely unknown.

Methods

Retrospectively, 69 bladder cancer samples

SUBMITTER: Song H 

PROVIDER: S-EPMC8080038 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature