The association between BOLD-based cerebrovascular reactivity (CVR) and end-tidal CO₂ in healthy subjects.

ABSTRACT: Cerebrovascular reactivity (CVR) mapping using CO₂-inhalation can provide important insight into vascular health. At present, blood-oxygenation-level-dependent (BOLD) MRI acquisition is the most commonly used CVR method due to its high sensitivity, high spatial resolution, and relatively straightforward processing. However, large variations in CVR across subjects and across different sessions of the same subject are often observed, which can cloud the ability of this promising measure in detecting diseases or monitoring treatment responses. The present work aims to identify the physiological components underlying the observed variability in CVR data. When studying the association between CVR value and the subject's CO₂ levels in a total of N = 253 healthy participants

SUBMITTER: Hou X 

PROVIDER: S-EPMC8080082 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature