Activated CD4⁺ T cells and CD14^hiCD16⁺ monocytes correlate with antibody response following influenza virus infection in humans.

ABSTRACT: The failure to mount an antibody response following viral infection or seroconversion failure is a largely underappreciated and poorly understood phenomenon. Here, we identified immunologic markers associated with robust antibody responses after influenza virus infection in two independent human cohorts, SHIVERS and FLU09, based in Auckland, New Zealand and Memphis, Tennessee, USA, respectively. In the SHIVERS cohort, seroconversion significantly associates with (1) hospitalization, (2) greater numbers of proliferating, activated CD4⁺ T cells, but not CD8⁺ T cells, in the periphery during the acute phase of illness, and (3) fewer inflammatory monocytes (CD14^hiCD16⁺) by convalescence. In the FLU09 cohort, fewer CD14^hiCD16⁺ mo

SUBMITTER: Wong SS 

PROVIDER: S-EPMC8080109 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature