Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation.

ABSTRACT:

Background

Questions remain regarding whether genetic influences on early life psychopathology overlap with cognition and show developmental variation.

Methods

Using data from 9,421 individuals aged 8-21 from the Philadelphia Neurodevelopmental Cohort, factors of psychopathology were generated using a bifactor model of item-level data from a psychiatric interview. Five orthogonal factors were generated: anxious-misery (mood and anxiety), externalizing (attention deficit hyperactivity and conduct disorder), fear (phobias), psychosis-spectrum, and a general factor. Genetic analyses were conducted on a subsample of 4,662 individuals of European American ancestry. A genetic relatedness matrix was used to estimate heritability of these factors, and genetic correlations with execu

SUBMITTER: Mollon J 

PROVIDER: S-EPMC8080212 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature