Association Between Age at Diabetes Onset and Subsequent Risk of Dementia.

ABSTRACT:

Importance

Trends in type 2 diabetes show an increase in prevalence along with younger age of onset. While vascular complications of early-onset type 2 diabetes are known, the associations with dementia remains unclear.

Objective

To determine whether younger age at diabetes onset is more strongly associated with incidence of dementia.

Design, setting, and participants

Population-based study in the UK, the Whitehall II prospective cohort study, established in 1985-1988, with clinical examinations in 1991-1993, 1997-1999, 2002-2004, 2007-2009, 2012-2013, and 2015-2016, and linkage to electronic health records until March 2019. The date of final follow-up was March 31, 2019.

Exposures

Type 2 diabetes, defined as a fasting blood glucose level greater than or equal

SUBMITTER: Barbiellini Amidei C 

PROVIDER: S-EPMC8080220 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature