An RNA-centric historical narrative around the Protein Data Bank.

ABSTRACT: Some of the amazing contributions brought to the scientific community by the Protein Data Bank (PDB) are described. The focus is on nucleic acid structures with a bias toward RNA. The evolution and key roles in science of the PDB and other structural databases for nucleic acids illustrate how small initial ideas can become huge and indispensable resources with the unflinching willingness of scientists to cooperate globally. The progress in the understanding of the molecular interactions driving RNA architectures followed the rapid increase in RNA structures in the PDB. That increase was consecutive to improvements in chemical synthesis and purification of RNA molecules, as well as in biophysical methods for structure determination and computer technology. The RNA modeling efforts from the

SUBMITTER: Westhof E 

PROVIDER: S-EPMC8080527 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature