β2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice.

ABSTRACT: In patients with chronic kidney disease, skeletal muscle dysfunction is associated with mortality. Uremic sarcopenia is caused by ageing, malnutrition, and chronic inflammation, but the molecular mechanism and potential therapeutics have not been fully elucidated yet. We hypothesize that accumulated uremic toxins might exert a direct deteriorative effect on skeletal muscle and explore the pharmacological treatment in experimental animal and culture cell models. The mice intraperitoneally injected with indoxyl sulfate (IS) after unilateral nephrectomy displayed an elevation of IS concentration in skeletal muscle and a reduction of instantaneous muscle strength, along with the predominant loss of fast-twitch myofibers and intramuscular reactive oxygen species (ROS) generation. The addition o

SUBMITTER: Higashihara T 

PROVIDER: S-EPMC8080640 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature