The use of pulse pressure variation for predicting impairment of microcirculatory blood flow.

ABSTRACT: Dynamic parameters of preload have been widely recommended to guide fluid therapy based on the principle of fluid responsiveness and with regard to cardiac output. An equally important aspect is however to also avoid volume-overload. This accounts particularly when capillary leakage is present and volume-overload will promote impairment of microcirculatory blood flow. The aim of this study was to evaluate, whether an impairment of intestinal microcirculation caused by volume-load potentially can be predicted using pulse pressure variation in an experimental model of ischemia/reperfusion injury. The study was designed as a prospective explorative large animal pilot study. The study was performed in 8 anesthetized domestic pigs (German landrace). Ischemia/reperfusion was induced during aorti

SUBMITTER: Behem CR 

PROVIDER: S-EPMC8080713 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature