Stress-induced differential gene expression in cardiac tissue.

ABSTRACT: The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as part of the stress response over activate beta adrenoceptors (β-AR) in the heart. Whether and how stress affects the expression of components of the intracellular environment in the heart is still, however, unknown. This paper used microarray to analyze the gene expression in the left ventricle wall of rats submitted to foot shock stress, treated or not treated with the selective β₂-AR antagonist ICI118,551 (ICI), compared to those of non-stressed rats also treated or not with ICI, respectively. The main findings were that stress induces changes in gene expression in the heart and that β₂-AR plays a role in this

SUBMITTER: de Carvalho AETS 

PROVIDER: S-EPMC8080723 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature