OCTAD: an open workspace for virtually screening therapeutics targeting precise cancer patient groups using gene expression features.

ABSTRACT: As the field of precision medicine progresses, treatments for patients with cancer are starting to be tailored to their molecular as well as their clinical features. The emerging cancer subtypes defined by these molecular features require that dedicated resources be used to assist the discovery of drug candidates for preclinical evaluation. Voluminous gene expression profiles of patients with cancer have been accumulated in public databases, enabling the creation of cancer-specific expression signatures. Meanwhile, large-scale gene expression profiles of cellular responses to chemical compounds have also recently became available. By matching the cancer-specific expression signature to compound-induced gene expression profiles from large drug libraries, researchers can prioritize small mol

SUBMITTER: Zeng B 

PROVIDER: S-EPMC8080884 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature