The Influence of Cerebral Small Vessel Disease on Static and Dynamic Functional Network Connectivity in Subjects Along Alzheimer's Disease Continuum.

ABSTRACT: Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder frequently accompanied by cerebral small vessel disease (CSVD). However, the influence of CSVD on the brain functional connectivity in subjects along the AD continuum is still largely unknown. The current study combined the static and dynamic functional network connectivity (FNC) to explore the underlying mechanism. Materials and Methods: In this study, we included 182 healthy controls, 27 individuals with subjective cognitive decline (SCD), 27 with SCD+CSVD, 104 with mild cognitive impairment (MCI), 123 with MCI+CSVD, 16 with AD, and 62 with AD+CSVD. We examined the static and dynamic FNC within the default mode, salience, and cognitive control domains. We also assessed the association

SUBMITTER: Li K 

PROVIDER: S-EPMC8080908 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature