AIM2 in regulatory T cells restrains autoimmune diseases.

ABSTRACT: The inflammasome initiates innate defence and inflammatory responses by activating caspase-1 and pyroptotic cell death in myeloid cells^1,2. It consists of an innate immune receptor/sensor, pro-caspase-1, and a common adaptor molecule, ASC. Consistent with their pro-inflammatory function, caspase-1, ASC and the inflammasome component NLRP3 exacerbate autoimmunity during experimental autoimmune encephalomyelitis by enhancing the secretion of IL-1β and IL-18 in myeloid cells^3-6. Here we show that the DNA-binding inflammasome receptor AIM2^7-10 has a T cell-intrinsic and inflammasome-independent role in the function of T regulatory (T_reg) cells. AIM2 is highly expressed by both human and mouse T_reg cells, is induced by TGFβ, and its promote

SUBMITTER: Chou WC 

PROVIDER: S-EPMC8080937 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature