EPR-based oximetric imaging: a combination of single point-based spatial encoding and T₁ weighting.

ABSTRACT:

Purpose

Spin-lattice relaxation rate (R₁ )-based time-domain EPR oximetry is reported for in vivo applications using a paramagnetic probe, a trityl-based Oxo71.

Methods

The R₁ dependence of the trityl probe Oxo71 on partial oxygen pressure (pO₂ ) was assessed using single-point imaging mode of spatial encoding combined with rapid repetition, similar to T₁ -weighted MRI, for which R₁ was determined from 22 repetition times ranging from 2.1 to 40.0 μs at 300 MHz. The pO₂ maps of a phantom with 3 tubes containing 2 mM Oxo71 solutions equilibrated at 0%, 2%, and 5% oxygen were determined by R₁ and apparent spin-spin relaxation rate ( R2*) simultaneously.

Results

The pO₂ maps derived fr

SUBMITTER: Matsumoto KI 

PROVIDER: S-EPMC8080971 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature