The mouse double minute 2 309T>G polymorphism and retinoblastoma risk: A meta-analysis.

ABSTRACT:

Purpose

Mouse double minute 2 (MDM2) homolog is a protein that in humans is encoded by the MDM2 gene. It is expressed in retinoblastoma (Rb) cells and acts as a key negative regulator of the p53 tumor suppressor gene. Several studies have investigated the association of Rb with MDM2 309T>G polymorphism, but the results were conflicting. To derive a more precise estimation of the association, we performed a meta-analysis of the relationship between MDM2 309T>G polymorphism with Rb in all published studies.

Methods

Published literature from PubMed and other databases were retrieved. All the reported studies evaluating the association between MDM2 309T>G polymorphism and Rb risk were included. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using the

SUBMITTER: Sooraj K 

PROVIDER: S-EPMC8081075 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature