The familial risk of infection-related hospitalization in children: A population-based sibling study.

ABSTRACT:

Objective

To assess the risk of severe childhood infections within families, we conducted a sibling analysis in a population-based cohort study with genealogical linkage. We investigated the sibling risk of hospitalization with common infections, a marker of severity. We hypothesized that having siblings hospitalized for infection would increase the proband's risk of admission with infection.

Study design

We used population data on Western Australian live-born singletons and their siblings between 1980 and 2014. Measures of infection were infection-related hospitalizations from discharge diagnostic codes. Exposure was having a sibling who had an infection-related hospitalization. Outcomes were infection-related hospitalizations in the child/proband. Probands were followed un

SUBMITTER: Miller JE 

PROVIDER: S-EPMC8081236 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature