Identification of long regulatory elements in the genome of Plasmodium falciparum and other eukaryotes.

ABSTRACT: Long regulatory elements (LREs), such as CpG islands, polydA:dT tracts or AU-rich elements, are thought to play key roles in gene regulation but, as opposed to conventional binding sites of transcription factors, few methods have been proposed to formally and automatically characterize them. We present here a computational approach named DExTER (Domain Exploration To Explain gene Regulation) dedicated to the identification of candidate LREs (cLREs) and apply it to the analysis of the genomes of P. falciparum and other eukaryotes. Our analyses show that all tested genomes contain several cLREs that are somewhat conserved along evolution, and that gene expression can be predicted with surprising accuracy on the basis of these long regions only. Regulation by cLREs exhibits very different beh

SUBMITTER: Menichelli C 

PROVIDER: S-EPMC8081344 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature