Impaired myocardial reserve underlies reduced exercise capacity and heart rate recovery in preterm-born young adults.

ABSTRACT:

Aims

We tested the hypothesis that the known reduction in myocardial functional reserve in preterm-born young adults is an independent predictor of exercise capacity (peak VO2) and heart rate recovery (HRR).

Methods and results

We recruited 101 normotensive young adults (n = 47 born preterm; 32.8 ± 3.2 weeks' gestation and n = 54 term-born controls). Peak VO2 was determined by cardiopulmonary exercise testing (CPET), and lung function assessed using spirometry. Percentage predicted values were then calculated. HRR was defined as the decrease from peak HR to 1 min (HRR1) and 2 min of recovery (HRR2). Four-chamber echocardiography views were acquired at rest and exercise at 40% and 60% of CPET peak power. Change in left ventricular ejection fraction from rest to each work inte

SUBMITTER: Huckstep OJ 

PROVIDER: S-EPMC8081423 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature