Breast Cancer Clinical Trials: The Landscape at the Uganda Cancer Institute and Lessons Learned.

ABSTRACT: The Uganda Cancer Institute, the sole national comprehensive cancer center in Uganda, has a long and rich history of clinical investigation and locally relevant cancer research. Given the increasing burden of breast cancer in Uganda and elsewhere in sub-Saharan Africa (SSA) and driven by the limited availability of immunohistochemistry (IHC), we launched a clinical trial aimed at evaluating locally available diagnostics to detect the presence of hormone receptors (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2. Preliminary data from 32 women in the diagnostic component of the study reveal high sensitivity and specificity for estrogen receptor and progesterone receptor and high specificity for human epidermal growth factor receptor 2 when comparing

SUBMITTER: Menon MP 

PROVIDER: S-EPMC8081514 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature