Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering.

ABSTRACT: Nerve injuries and neurodegenerative disorders remain serious challenges, owing to the poor treatment outcomes of in situ neural stem cell regeneration. The most promising treatment for such injuries and disorders is stem cell-based therapies, but there remain obstacles in controlling the differentiation of stem cells into fully functional neuronal cells. Various biochemical and physical approaches have been explored to improve stem cell-based neural tissue engineering, among which electrical stimulation has been validated as a promising one both in vitro and in vivo. Here, we summarize the most basic waveforms of electrical stimulation and the conductive materials used for the fabrication of electroactive substrates or scaffolds in neural tissue engineering. Various intensities and

SUBMITTER: Cheng H 

PROVIDER: S-EPMC8081629 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature