Universal nomenclature for oxytocin-vasotocin ligand and receptor families.

ABSTRACT: Oxytocin (OXT; hereafter OT) and arginine vasopressin or vasotocin (AVP or VT; hereafter VT) are neurotransmitter ligands that function through specific receptors to control diverse functions^1,2. Here we performed genomic analyses on 35 species that span all major vertebrate lineages, including newly generated high-contiguity assemblies from the Vertebrate Genomes Project^3,4. Our findings support the claim⁵ that OT (also known as OXT) and VT (also known as AVP) are adjacent paralogous genes that have resulted from a local duplication, which we infer was through DNA transposable elements near the origin of vertebrates and in which VT retained more of the parental sequence. We identified six major oxytocin-vasotocin receptors among vertebrates. We propose tha

SUBMITTER: Theofanopoulou C 

PROVIDER: S-EPMC8081664 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature