Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma.

ABSTRACT:

Background

Nothing is known about the mechanisms by which increased ceramide levels in the lung contribute to allergic responses and asthma severity.

Objective

We sought to investigate the functional role of ceramide in mouse models of allergic airway disease that recapitulate the cardinal clinical features of human allergic asthma.

Methods

Allergic airway disease was induced in mice by repeated intranasal administration of house dust mite or the fungal allergen Alternaria alternata. Processes that can be regulated by ceramide and are important for severity of allergic asthma were correlated with ceramide levels measured by mass spectrometry.

Results

Both allergens induced massive pulmonary apoptosis and also significantly increased reactive oxygen species in t

SUBMITTER: James BN 

PROVIDER: S-EPMC8081742 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature