Prioritizing Molecular Biomarkers in Asthma and Respiratory Allergy Using Systems Biology.

ABSTRACT: Highly prevalent respiratory diseases such as asthma and allergy remain a pressing health challenge. Currently, there is an unmet need for precise diagnostic tools capable of predicting the great heterogeneity of these illnesses. In a previous study of 94 asthma/respiratory allergy biomarker candidates, we defined a group of potential biomarkers to distinguish clinical phenotypes (i.e. nonallergic asthma, allergic asthma, respiratory allergy without asthma) and disease severity. Here, we analyze our experimental results using complex algorithmic approaches that establish holistic disease models (systems biology), combining these insights with information available in specialized databases developed worldwide. With this approach, we aim to prioritize the most relevant biomarkers according t

SUBMITTER: Cremades-Jimeno L 

PROVIDER: S-EPMC8081895 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature