DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.

ABSTRACT: Viruses and hosts have coevolved for millions of years, leading to the development of complex host-pathogen interactions. Influenza A virus (IAV) causes severe pulmonary pathology and is a recurrent threat to human health. Innate immune sensing of IAV triggers a complex chain of host responses. IAV has adapted to evade host defense mechanisms, and the host has coevolved to counteract these evasion strategies. However, the molecular mechanisms governing the balance between host defense and viral immune evasion is poorly understood. Here, we show that the host protein DEAD-box helicase 3 X-linked (DDX3X) is critical to orchestrate a multifaceted antiviral innate response during IAV infection, coordinating the activation of the nucleotide-binding oligomerization domain-like receptor with a py

SUBMITTER: Kesavardhana S 

PROVIDER: S-EPMC8081917 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature