Characterization of the Onychomatricodermis Containing Onychofibroblasts of the Nail Unit : Histology, Immunohistochemistry, and Electron Microscopic Study.

ABSTRACT:

Background

We recently discovered the presence of specialized nail mesenchyme below the nail matrix and designated it as onychomatricodermis.

Objective

We did further research to characterize the histologic, histochemical, immunohistochemical and ultrastructural features of the onychomatricodermis containing onychofibroblasts in the nail unit.

Methods

Ten polydactyly nail unit specimens and 8 nail matrix biopsies were included. H&E-stained slides were reviewed. We did Alcian blue staining and Masson Trichrome staining, as well as immunohistochemical staining for type I collagen, CD10, CD13 and CD34. In addition, polydactyly nail units were examined by transmission electron microscopy.

Results

In H&E staining, the specialized mesenchyme called onychomatricodermi

SUBMITTER: Lee D 

PROVIDER: S-EPMC8082007 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature