The Establishment of New Thresholds for PLND-Validated Clinical Nomograms to Predict Non-Regional Lymph Node Metastases: Using ⁶⁸Ga-PSMA PET/CT as References.

ABSTRACT:

Purpose

PLND (pelvic lymph node dissection)-validated nomograms are widely accepted clinical tools to determine the necessity of PLND by predicting the metastasis of lymph nodes (LNMs) in pelvic region. However, these nomograms are in lacking of a threshold to predict the metastasis of extrareolar lymph nodes beyond pelvic region, which is not suitable for PLND. The aim of this study is to evaluate a threshold can be set for current clinical PLND-validated nomograms to predict extrareolar LN metastases beyond pelvic region in high-risk prostate cancer patients, by using ⁶⁸Ga-PSMA PET/CT as a reference to determine LN metastases (LNMs).

Experimental design

We performed a retrospective analysis of 57 high-risk treatment-naïve PC patients in a large tertiary care hos

SUBMITTER: Jiao J 

PROVIDER: S-EPMC8082014 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature