Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis.

ABSTRACT:

Background

Protective ventilation with lower tidal volumes reduces systemic and organ-specific inflammation. In sepsis-induced encephalopathy or acute brain injury the use of protective ventilation has not been widely investigated (experimentally or clinically). We hypothesized that protective ventilation would attenuate cerebral inflammation in a porcine endotoxemic sepsis model. The aim of the study was to study the effect of tidal volume on cerebral inflammatory response, cerebral metabolism and brain injury. Nine animals received protective mechanical ventilation with a tidal volume of 6 mL × kg^-1 and nine animals were ventilated with a tidal volume of 10 mL × kg^-1. During a 6-h experiment, the pigs received an endotoxin intravenous infusion of 0.25 µg × k

SUBMITTER: Nyberg A 

PROVIDER: S-EPMC8082058 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature