Assessment of Diagnostic Strategy for Mucous Membrane Pemphigoid.

ABSTRACT:

Importance

An accurate diagnosis of mucous membrane pemphigoid (MMP) is essential to reduce diagnostic and therapeutic delay.

Objective

To assess the diagnostic accuracy of direct immunofluorescence microscopy on mucosal biopsy specimens and immunoserology in a large cohort of patients with suspected MMP.

Design, setting, and participants

This retrospective cohort study was carried out in a single tertiary care center for blistering diseases between January 2002 and March 2019. Eligible participants were patients with suspected MMP and paired data on at least a mucosal biopsy specimen for direct immunofluorescence microscopy (DIF) and indirect immunofluorescence microscopy (IIF) on a human salt-split skin substrate (SSS). In addition, an optional DIF test on a skin bi

SUBMITTER: Rashid H 

PROVIDER: S-EPMC8082433 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature