Immune-mediated diseases and risk of Crohn's disease or ulcerative colitis: a prospective cohort study.

ABSTRACT:

Background

Although immune-mediated diseases (IMDs) including inflammatory bowel diseases (IBDs) are known to cluster, to what extent this is due to common environmental influences is unknown.

Aim

To examine the incidence of IBD in individuals with another IMD.

Methods

We used data from the prospective Nurses' Health Study II cohort (1995-2017) to examine the effect of diagnoses of several common IMDs on subsequent risk of Crohn's disease (CD) or ulcerative colitis (UC) using Cox proportional hazards models, adjusting for detailed diet and lifestyle confounders.

Results

We documented 132 cases of CD and 186 cases of UC over 2 016 163 person-years of follow-up (median age at IBD diagnosis 50 years). Compared to participants with no history of IMD, the HRs of CD

SUBMITTER: Lo CH 

PROVIDER: S-EPMC8082435 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature