Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is an emerging, chronic, rare allergic disease associated with marked eosinophil accumulation in the esophagus. Previous genome-wide association studies have provided strong evidence for 3 genome-wide susceptibility loci.

Objective

We sought to replicate known and suggestive EoE genetic risk loci and conduct a meta-analysis of previously reported data sets.

Methods

An EoE-Custom single-nucleotide polymophism (SNP) Chip containing 956 candidate EoE risk single-nucleotide polymorphisms was used to genotype 627 cases and 365 controls. Statistical power was enhanced by adding 1959 external controls and performing meta-analyses with 2 independent EoE genome-wide association studies.

Results

Meta-analysis identified replicate

SUBMITTER: Kottyan LC 

PROVIDER: S-EPMC8082436 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature