The safety of polymyxin antibiotics.

ABSTRACT:

Introduction

The emergence of multidrug-resistant gram-negative bacteria has led to the increasing use of polymyxins. Nephrotoxicity and, to a lesser degree, neurotoxicity occur often during systemic polymyxin therapy. Scientific evidence regarding safety associated with polymyxins remains limited.

Areas covered

Case reports/case series, observational studies and clinical trials assessing safety and toxicity of polymyxins were critically reviewed.

Expert opinion

Polymyxins are drugs with a narrow therapeutic range. Nephrotoxicity is associated with both host factors and polymyxin exposure, and recent studies suggest that the relative risk of nephrotoxicity is similar for colistin and polymyxin B. Studies that have examined the safety of polymyxins have several limitat

SUBMITTER: Kelesidis T 

PROVIDER: S-EPMC8082492 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature