Mitigation of Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells in vitro by Transgenic Erythropoietin-Expressing Mesenchymal Stem Cells.

ABSTRACT: Mesenchymal stem cells (MSC) have shown promise in restoring the vision of patients in clinical trials. However, this therapeutic effect is not observed in every treated patient and is possibly due to the inefficacies of cell delivery and high cell death following transplantation. Utilizing erythropoietin can significantly enhance the regenerative properties of MSCs and hence improve retinal neuron survivability in oxidative stress. Hence, this study aimed to investigate the efficacy of conditioned medium (CM) obtained from transgenic human erythropoietin-expressing MSCs (MSC _EPO ) in protecting human retinal pigment epithelial cells from sodium iodate (NaIO₃)-induced cell death. Human MSC and MSC _EPO were first cultured to obtain conditioned

SUBMITTER: Koh AE 

PROVIDER: S-EPMC8082501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature