Peptide Probes of Colistin Resistance Discovered via Chemically Enhanced Phage Display.

ABSTRACT: Colistin is an antibiotic of last resort used to treat infections caused by multidrug-resistant Gram-negative bacterial pathogens. The recent surge in reported cases of colistin-resistant infections urgently calls for fast and reliable diagnostic methods, which can be used for the facile detection and proper treatment of these challenging infections. A major mechanism of colistin resistance involves phosphoethanolamine (PE) modification of lipopolysaccharide (LPS), the molecular target of colistin. This LPS modification mechanism has been recently reported to be transferrable via a plasmid-carried mcr-1 gene, which is particularly concerning as it may readily confer colistin resistance to a wide array of bacterial pathogens. To develop molecular tools to allow facile detection of co

SUBMITTER: Kelly M 

PROVIDER: S-EPMC8082519 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature