Uptake and safety of hepatitis A vaccination during pregnancy: A Vaccine Safety Datalink study.

ABSTRACT:

Introduction

Infection with hepatitis A virus (HAV) during pregnancy, although uncommon, is associated with gestational complications and pre-term labor. Hepatitis A vaccine (HepA) is recommended for anyone at increased risk for contracting hepatitis A, including women at risk who are also pregnant. Limited data are available on the safety of maternal HepA vaccination.

Objectives

Assess the frequency of maternal HepA receipt and evaluate the potential association between maternal vaccination and pre-specified maternal and infant safety outcomes.

Methods

A retrospective cohort of pregnancies in the Vaccine Safety Datalink (VSD) resulting in live births from 2004 through 2015 was included. Pregnancies with HepA exposure were compared to those with other vaccine exposure

SUBMITTER: Groom HC 

PROVIDER: S-EPMC8082525 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature