Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome.

ABSTRACT:

Background

Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS.

Methods

Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward (bottom-up) and feedback (top-down) activity.

Results

We find individuals with PMS display increased alph

SUBMITTER: Mariscal MG 

PROVIDER: S-EPMC8082621 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature