The TonB system in Aeromonas hydrophila NJ-35 is essential for MacA₂B₂ efflux pump-mediated macrolide resistance.

ABSTRACT: The TonB system is generally considered as an energy transporting device for the absorption of nutrients. Our recent study showed that deletion of this system caused a significantly increased sensitivity of Aeromonas hydrophila to the macrolides erythromycin and roxithromycin, but had no effect on other classes of antibiotics. In this study, we found the sensitivity of ΔtonB123 to all macrolides tested revealed a 8- to 16-fold increase compared with the wild-type (WT) strain, but this increase was not related with iron deprivation caused by tonB123 deletion. Further study demonstrated that the deletion of tonB123 did not damage the integrity of the bacterial membrane but did hinder the function of macrolide efflux. Compared with the WT strain, deletion of macA₂B₂, one

SUBMITTER: Dong Y 

PROVIDER: S-EPMC8082627 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature