Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study.

ABSTRACT:

Background

Circulating folate, vitamin B12 and homocysteine concentrations during fetal development have been associated with health outcomes in childhood. Changes in fetal DNA methylation may be an underlying mechanism. This may be reflected in altered epigenetic aging of the fetus, as compared to chronological aging. The difference between gestational age derived in clinical practice and gestational age predicted from neonatal DNA methylation data is referred to as gestational age acceleration. Differences in circulating folate, vitamin B12 and homocysteine concentrations during fetal development may be associated with gestational age acceleration.

Results

Up to 1346 newborns participating in the Generation R Study, a population-based prospective cohort study, had both cor

SUBMITTER: Monasso GS 

PROVIDER: S-EPMC8082638 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature