Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases.

ABSTRACT: Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury mechanism, underlying conditions, and secondary injury. Pre-clinical and clinical researchers face challenges with reproducibility that negatively impact translation and therapeutic development for improved TBI patient outcomes. To address this challenge, TBI Pre-clinical Working Groups expanded upon previous efforts and developed common data elements (CDEs) to describe the most frequently used experimental parameters. The working groups created 913 CDEs to describe study metadata, animal characteristics, animal history, injury models, and behavioral tests. Use cases applied a set of commonly used CDEs to address and evaluate the degree of missing data resulting from combining legacy data from dif

SUBMITTER: LaPlaca MC 

PROVIDER: S-EPMC8082734 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature