Five-year microevolution of a multidrug-resistant Mycobacterium tuberculosis strain within a patient with inadequate compliance to treatment.

ABSTRACT:

Background

Whole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought. Compartmentalized infections, exogenous reinfections, and microevolution are manifestations of this clonal complexity. The analysis of the mechanisms causing the microevolution -the genetic variability of M. tuberculosis at short time scales- of a parental strain into clonal variants with a patient is a relevant issue that has not been yet completely addressed. To our knowledge, a whole genome sequence microevolution analysis in a single patient with inadequate adherence to treatment has not been previously reported.

Case presentation

In this work, we applied whole genome sequencing analysis for a more in-depth analysis of the

SUBMITTER: Fernandez Do Porto DA 

PROVIDER: S-EPMC8082761 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature