Non-contrast cardiovascular magnetic resonance detection of myocardial fibrosis in Duchenne muscular dystrophy.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) leads to progressive cardiomyopathy. Detection of myocardial fibrosis with late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) is critical for clinical management. Due to concerns of brain deposition of gadolinium, non-contrast methods for detecting and monitoring myocardial fibrosis would be beneficial.

Objectives

We hypothesized that native T1 mapping and/or circumferential (ε_cc) and longitudinal (ε_ls) strain can detect myocardial fibrosis.

Methods

156 CMRs with gadolinium were performed in 66 DMD boys and included: (1) left ventricular ejection fraction (LVEF), (2) LGE, (3) native T1 mapping and myocardial tagging (ε_cc-tag measured using harmonic phase analysis).

SUBMITTER: Raucci FJ 

PROVIDER: S-EPMC8082768 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature