Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis.

ABSTRACT:

Background

Post-artesunate delayed haemolysis (PADH) is common after severe malaria episodes. PADH is related to the "pitting" phenomenon and the synchronous delayed clearance of once-infected erythrocytes, initially spared during treatment. However, direct antiglobulin test (DAT) positivity has been reported in several PADH cases, suggesting a contribution of immune-mediated erythrocyte clearance. The aim of the present study was to compare clinical features of cases presenting a positive or negative DAT.

Methods

Articles reporting clinical data of patients diagnosed with PADH, for whom DAT had been performed, were collected from PubMed database. Data retrieved from single patients were extracted and univariate analysis was performed in order to identify features potentiall

SUBMITTER: Ascoli Bartoli T 

PROVIDER: S-EPMC8082776 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature